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[[Image:banner.jpg|thumb|right|400px|''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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  {{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
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== Welcome ==
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
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'''The Neurohydrodynamics and Medical Technology Lab''' (NMTL) is led by [[Bryn Martin]] in conjunction with the [http://lhtc.epfl.ch Laboratory of Hemodynamics and Cardiovascular Technology] at the Swiss Federal Institute of Technology [http://www.epfl.ch (EPFL)] and [[collaborators|collaborating]] institutions.  We investigate the pathophysiology of craniospinal and cerebrovascular disorders from a '''hydrodynamic''' and '''biomechanical''' perspective and develop related medical technologies.
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
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== Purpose ==
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== Welcome to the NIML==
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The purpose of neurohydrodynamics.com is to:
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies. 
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# foster collaboration and discussion between medical doctors and engineers
 
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# provide in vivo and in vitro experimental data for improving modeling capabilities
 
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# increase interest in heurohydrodynamic disorder research
 
  
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== What is neurohydrodynamics? ==
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=== Team ===
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'''[http://en.wikipedia.org/wiki/Neurohydrodynamics Neurohydrodynamics]''' is a division of [http://en.wikipedia.org/wiki/Neuroengineering neural engineering] that investigates the [http://en.wikipedia.org/wiki/Hydrodynamics hydrodynamics] of the neurological system in health and disease.  It applies engineering principles and design concepts to neural engineering to help close the gap between [http://en.wikipedia.org/wiki/Fluid_mechanics fluid mechanics] and [http://en.wikipedia.org/wiki/Neurosurgical neurosurgical] and [http://en.wikipedia.org/wiki/Neurological neurological] [http://en.wikipedia.org/wiki/Medicine medicine].  It combines fluid mechanics principles with [http://en.wikipedia.org/wiki/Neuroscience neuroscience] to improve neurological disorder healthcare in terms of medical diagnosis, monitoring, and therapy.
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*[[Team]]   
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*[[Collaborators]]
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*[[NIML Lab Fun!]]
  
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''' Key words''':  [http://en.wikipedia.org/wiki/Neurohydrodynamics Neurohydrodynamics], [http://en.wikipedia.org/wiki/Cerebrospinal_fluid cerebrospinal fluid], craniospinal disorders,  [http://en.wikipedia.org/wiki/Chiari_malformation chiari malformation], [http://en.wikipedia.org/wiki/Syringomyelia syringomyelia], [http://en.wikipedia.org/wiki/Hydrocephalus hydrocephalus], [http://en.wikipedia.org/wiki/Neural_drug_delivery_systems neural drug delivery], [http://en.wikipedia.org/wiki/Spinal_cord#Blood_supply spinal cord blood flow], [http://en.wikipedia.org/wiki/Cerebral_blood_flow cerebral blood flow], [http://en.wikipedia.org/wiki/Cerebral_perfusion_pressure cerebral perfusion and autoregulation], [http://en.wikipedia.org/wiki/Sleep_disorders sleep disorders], [http://en.wikipedia.org/wiki/Sleep_apnea sleep apnea], [http://en.wikipedia.org/wiki/Continuous_positive_airway_pressure continuous positive airway pressure], [http://en.wikipedia.org/wiki/Computational_fluid_dynamics computational fluid dynamics], [http://en.wikipedia.org/wiki/Magnetic_resonance_angiography MRI], 4DMRI and pcMRI, [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Biomechanics#Biofluid_mechanics biofluid mechanics], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Medical_technology medical technology], [http://en.wikipedia.org/wiki/Neuromonitoring neuromonitoring].
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===Job Opportunities in the NIML===
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* [[Open Positions|Open Research Assistant Positions]]
  
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== Research areas ==
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===Mission===
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[[Image:projects.jpg|thumb|right|400px|Ongoing research projects at the Laboratory of Neurohydrodynamics and Medical Technology (NMTL).]]
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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Please click on the links below to learn more about the current, available, and past research projects at the NMTL.
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#CSF physiology, Chiari malformation & hydrocephalus
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*[[Current projects]]
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
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*[[Available projects]] for M.S. or B.S. students
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#Traumatic brain injury biomechanics
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*[[Past projects]]
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
  
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The '''NMTL''''s research includes in vivo, in vitro, and in silico studies that are conducted closely with medical collaborators and can be divided into projects involving 1) clinical tools and measurements and 2) modeling (see figure below). The names adjacent to each box in the figure indicate key collaborators involved with each project. For a complete list of collaborators click [[collaborators|here]].
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=== Research ===
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*[[Current projects]] that we are working on.
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*[[Past projects]] that have been completed.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
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We are currently involved in the following research areas:
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=== Other Information ===
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*[[Information for New NIML Student Researchers]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
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*[[NIML Facilities|Facilities]] available at the NIML.
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Software]] that we use in the lab.
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*[[Student Advising]]
  
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:'''Clinical tools and measurements'''
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== Links ==
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:*Intraoperative aortic graft hemodynamics
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*[[Links]] to related laboratories, conferences, and organizations.
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:*Continuous positive airway pressure (CPAP): influence on the cardiovascular and cerebrospinal fluid system
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
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:*4D MRI in craniospinal disorders
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*[https://help.uidaho.edu/ UIdaho Help System]
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:*4D MRI in cerebral blood flow and cerebrospinal fluid hydrodynamics
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
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:*Cerebrospinal fluid pulse wave velocity in craniospinal disorders
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]
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:'''Modeling'''
 
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:*Coupled cardiovascular and cerebrospinal fluid (CSF) system
 
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:*Hydrocephalus
 
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:*Spinal cord blood flow
 
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:*Aortic graft hemodynamics
 
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:*Cerebrospinal fluid: in vitro and computational fluid dynamics models
 
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== External links ==
 
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*Take a moment to visit the NMTL Youtube channel to see some videos of our work [http://www.youtube.com/user/csflab].
 
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*Click [[links| here]] for external links to related laboratories, conferences, and organizations.
 
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== References ==
 
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{{reflist}}
 

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links

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