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[[Image:banner.jpg|thumb|right|400px|''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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  {{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
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== Welcome ==
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
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'''The Neurohydrodynamics and Medical Technology Lab''' (NMTL) is led by Dr. [[Bryn Martin]] in conjunction with the [http://lhtc.epfl.ch Laboratory of Hemodynamics and Cardiovascular Technology] at the Swiss Federal Institute of Technology [http://www.epfl.ch (EPFL)].  We investigate the pathophysiology of craniospinal and cerebrovascular disorders from a '''hydrodynamic''' and '''biomechanical''' perspective and develop related medical technologies.
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
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== Purpose ==
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== Welcome to the NIML==
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The purpose of neurohydrodynamics.com is to:
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies. 
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# foster collaboration and discussion between medical doctors and engineers
 
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# provide in vivo and in vitro experimental data for improving modeling capabilities
 
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# increase interest in heurohydrodynamic disorder research
 
  
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''' Key words''':  Neurohydrodynamics, [http://en.wikipedia.org/wiki/Cerebrospinal_fluid cerebrospinal fluid], craniospinal disorders,  [http://en.wikipedia.org/wiki/Chiari_malformation chiari malformation], [http://en.wikipedia.org/wiki/Syringomyelia syringomyelia], [http://en.wikipedia.org/wiki/Hydrocephalus hydrocephalus], spinal drug delivery, [http://en.wikipedia.org/wiki/Spinal_cord#Blood_supply spinal cord blood flow], [http://en.wikipedia.org/wiki/Cerebral_blood_flow cerebral blood flow], [http://en.wikipedia.org/wiki/Cerebral_perfusion_pressure cerebral perfusion and autoregulation], [http://en.wikipedia.org/wiki/Sleep_disorders sleep disorders], [http://en.wikipedia.org/wiki/Sleep_apnea sleep apnea], [http://en.wikipedia.org/wiki/Continuous_positive_airway_pressure continuous positive airway pressure], [http://en.wikipedia.org/wiki/Computational_fluid_dynamics computational fluid dynamics], 4DMRI, [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Biomechanics#Biofluid_mechanics biofluid mechanics], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Medical_technology medical technology], [http://en.wikipedia.org/wiki/Neuromonitoring neuromonitoring].
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=== Team ===
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*[[Team]]
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*[[Collaborators]]
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*[[NIML Lab Fun!]]
  
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== Research areas ==
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===Job Opportunities in the NIML===
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*[[Current projects]]
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* [[Open Positions|Open Research Assistant Positions]]
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*[[Available projects]] for M.S. or B.S. students
 
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*[[Past projects]]
 
  
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== What is neurohydrodynamics? ==
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===Mission===
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*Please click on the following link for background information on [[neurohydrodynamics]].
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector.  Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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#CSF physiology, Chiari malformation & hydrocephalus
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
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#Traumatic brain injury biomechanics
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
  
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== External links ==
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=== Research ===
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*Take a moment to visit the NMTL Youtube channel to see some videos of our work [http://www.youtube.com/user/csflab].
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*[[Current projects]] that we are working on.
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*External [[links]] to related laboratories, conferences, and organizations.
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*[[Past projects]] that have been completed.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
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== References ==
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=== Other Information ===
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{{reflist}}
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*[[Information for New NIML Student Researchers]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
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*[[NIML Facilities|Facilities]] available at the NIML.
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Software]] that we use in the lab.
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*[[Student Advising]]
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== Links ==
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*[[Links]] to related laboratories, conferences, and organizations.
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
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*[https://help.uidaho.edu/ UIdaho Help System]
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links

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