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[[Image:banner.jpg|thumb|right|400px|''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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  {{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
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== Welcome ==
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
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'''The Neurohydrodynamics and Medical Technology Lab''' (NMTL) is led by Dr. [[Bryn Martin]] in conjunction with the [http://lhtc.epfl.ch Laboratory of Hemodynamics and Cardiovascular Technology] at the Swiss Federal Institute of Technology [http://www.epfl.ch (EPFL)].  We investigate the pathophysiology of craniospinal and cerebrovascular disorders from a '''hydrodynamic''' and '''biomechanical''' perspective and develop related medical technologies.
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
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The purpose of neurohydrodynamics.com is to:
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== Welcome to the NIML==
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# foster collaboration and discussion between medical doctors and engineers
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies. 
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# provide in vivo and in vitro experimental data for improving modeling capabilities
 
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# increase interest in heurohydrodynamic disorder research
 
  
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''' Key words''': Neurohydrodynamics, cerebrospinal fluid, craniospinal disorders,  chiari malformation, syringomyelia, hydrocephalus, spinal drug delivery, spinal cord blood flow, cerebral blood flow, cerebral autoregulation, sleep disorders, sleep apnea, continuous positive airway pressure, computational fluid dynamics, 4DMRI, neuroengineering, neuroscience, biofluid mechanics, neuroscience, neuroengineering, medical technology, neuromonitoring.
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=== Team ===
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*[[Team]]  
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*[[Collaborators]]
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*[[NIML Lab Fun!]]
  
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Please click on the following link for background information on [[neurohydrodynamics]].
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===Job Opportunities in the NIML===
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* [[Open Positions|Open Research Assistant Positions]]
  
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Take a moment to visit the NMTL Youtube channel to see some videos of our work [http://www.youtube.com/user/csflab].
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===Mission===
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector.  Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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#CSF physiology, Chiari malformation & hydrocephalus
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
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#Traumatic brain injury biomechanics
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
  
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== Projects ==
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=== Research ===
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*[[Current projects]]
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*[[Current projects]] that we are working on.
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*[[Available projects]] for M.S. or B.S. students
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*[[Past projects]] that have been completed.
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*[[Past projects]]
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
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kkk
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=== Other Information ===
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*[[Quantification of the Modulus of Elasticity and Dynamic Properties of Sylgard for Various Mixing Ratios, 2003-2006]]
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*[[Information for New NIML Student Researchers]]
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*[[MR Measurement of Cerebrospinal Fluid Velocity Wave Speed in the Spinal Canal]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
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*[[Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories]]
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*[[NIML Facilities|Facilities]] available at the NIML.
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*[[The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis]]
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Syringomyelia Hydrodynamics: An In Vitro Study Based on In Vivo Measurements]]
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*[[Software]] that we use in the lab.
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*[[Student Advising]]
  
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== External links ==
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== Links ==
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'''Cerebrospinal Fluid Research Laboratories'''
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*[[Links]] to related laboratories, conferences, and organizations.
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:[http://lhtc.epfl.ch/ EPFL Hemodynamics and Cardiovascular Technology Lab]
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
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:[http://www.biofluids.net University of Akron Biofluids Lab]
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*[https://help.uidaho.edu/ UIdaho Help System]
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:[http://www.smartshunt.ethz.ch/ ETH smart shunt hydrocephalus project]
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
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:[http://www.eng.ox.ac.uk/fbg/ Fluidics and Biocomplexity Group]
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]
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:[http://www.u-picardie.fr/labo/UGBM/Index.htm Research Group Multimodal Analysis of Brain Function]
 
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:[http://lppd.uic.edu/research/research.html Laboratory of Product and Process Design]
 
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'''Lymphatic Research Laboratories'''
 
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:[http://www.sunnybrook.ca/research/content/?page=sri_groups_lymph_home Lymphatic Research Group at Sunnybrook Toronto]
 
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'''Vascular Research Laboratories'''
 
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:[http://acoustics.mie.uic.edu/ University of Illinois at Chicago Acoustics and Vibrations Lab]
 
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:[http://www.ices.cmu.edu/vascular-biomechanics/ CMU Vascular Biomechanics Lab]
 
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:[http://www.pitt.edu/~msacks/etml.html UPitt Engineered Tissue Mechanics and Mechanobiology Lab]
 
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:[http://www.surgery.upmc.edu/vorplab/bios/vorp.htm UPitt Vascular Bioengineering Lab]
 
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'''Organizations and foundations'''
 
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:[http://www.conquerchiari.org/index.htm Conquer Chiari.org]
 
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:[http://www.asap.org American Syringomyelia Alliance Project]
 
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:[http://www.columnofhope.org/ Column of Hope]
 
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:[http://www.csfinfo.org/ Chiari Syringomyelia Foundation]
 
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'''Societies'''
 
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:[http://www.iscbfm.org/ International Society for Cerebral Blood Flow and Metabolism]
 
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:[http://www.srhsb.org/ Society for Research into Hydrocephalus and Spina Bifida]
 
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'''Related conferences'''
 
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:[http://www.icp2010.eu/ ICP 2010]
 
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:[http://www.porstmann-kongresse.de/syringomyelia2010/ Syringomyelia 2010]
 
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:[http://www.hydrocephalus2008.com/copenhagen.htm International society for hydrocephalus and cerebrospinal fluid disorders]
 
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:[http://www2.kenes.com/brain/pages/home.aspx International symposium on cerebral blood flow, metabolism and function]
 
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:[http://www.conquerchiari.org/Res%20Conf%202010/Research%20Conference%202010.htm Conquer chiari research conference]
 
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:[http://www.acns.org/ American Clinical Neurophysiology Society]
 
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== References ==
 
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{{reflist}}
 

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links

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