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[[Image:banner.jpg|thumb|right|400px|''in silico'', ''in vivo'', and ''in vitro'' CSF experimentsLaser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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  {{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
= Welcome =
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
'''The Neurohydrodynamics and Medical Technology Lab''' (NMTL) is led by [[Bryn Martin]] in conjunction with the [[Laboratory of Hemodynamics and Cardiovascular Technology]] at the Swiss Federal Institute of Technology (EPFL).  We investigate the pathophysiology of craniospinal and cerebrovascular disorders from a '''hydrodynamic''' and '''biomechanical''' perspective and develop related medical technologies.  Please direct questions to [[Bryn Martin]].
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
'''Purpose of neurohydrodynamics.com'''
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== Welcome to the NIML==
# '''foster''' collaboration and discussion between medical doctors and engineers
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]]. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies. 
# '''provide''' in vivo and in vitro experimental data for improving modeling capabilities
 
# '''increase''' interest in heurohydrodynamic disorder research
 
  
''' Key words '''
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=== Team ===
Neurohydrodynamics, cerebrospinal fluid, craniospinal disorders, chiari malformation, syringomyelia, hydrocephalus, spinal drug delivery, spinal cord blood flow, cerebral blood flow, cerebral autoregulation, sleep disorders, sleep apnea, continuous positive airway pressure, computational fluid dynamics, 4DMRI, neuroengineering, neuroscience, biofluid mechanics, neuroscience, neuroengineering, medical technology, neuromonitoring.
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*[[Team]]  
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*[[Collaborators]]
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*[[NIML Lab Fun!]]
  
''' Background information on neurohydrodynamics'''
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===Job Opportunities in the NIML===
Information on [[cerebrospinal fluid biomechanics]] from an anatomical and physiological perspective is provided.
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* [[Open Positions|Open Research Assistant Positions]]
  
= Available projects for M.S. or B.S. students=
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===Mission===
The NMTL is seeking motivated and clever students to join our research team.  Please click on links below to learn more about projects that we are currently seeking people to join.  
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
 
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#CSF physiology, Chiari malformation & hydrocephalus
'''Cerebrospinal fluid related'''
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
*[[Measurement of brain volume change due to acute modification of intracranial pressure]]
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#Traumatic brain injury biomechanics
*[[Construction and MRI testing of a 3D model of the spinal subarachnoid space]]
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#Advanced MRI and ultrasound imaging and post-processing techniques
*[[Measurement and characterization of cough induced subarachnoid space pressure wave reverberations during lumbar puncture]]
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#Computational fluid dynamics simulation of biological flows
*[[What is the relative distribution of spinal subarachnoid space volumetric compliance in healthy subjects?]]
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
  
'''Sleep and breathing related'''
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=== Research ===
*[[Physiological impact of continuous positive airway pressure (CPAP) on cerebral blood flow and cerebrospinal fluid dynamics in healthy awake volunteers (MRI)]]
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*[[Current projects]] that we are working on.
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*[[Past projects]] that have been completed.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
'''Cardiovascular related'''
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=== Other Information ===
*[[A prospective and controlled clinical study to evaluate the effect of ascending aortic reconstructive surgery on cardiovascular hemodynamics]]
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*[[Information for New NIML Student Researchers]]
*[[non-invasive measurement of cerebrovascular properties]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
*[[design and development of an improved vascular graft]]
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*[[NIML Facilities|Facilities]] available at the NIML.
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Software]] that we use in the lab.
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*[[Student Advising]]
  
'''Medical technology related'''
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== Links ==
*[[a low-cost directional hearing aid]]
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*[[Links]] to related laboratories, conferences, and organizations.
 
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
= Current projects =
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*[https://help.uidaho.edu/ UIdaho Help System]
'''CSF related'''
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
*[[Understanding the coupling of cranial blood flow and the cerebrospinal fluid system: an in vivo and in silico study]]
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]
*[[Physiological impact of continuous positive airway pressure (CPAP) on total cerebral blood flow in healthy awake volunteers (ultrasound study)]]
 
*[[Are changes in intracranial pressure detectable by measurement of the cerebrospinal fluid velocity wave speed in the spinal canal?]]
 
*[[in vitro and in silico modeling of CSF wave transmission in the spinal subarachnoid space]]
 
*[[An in vitro examination of the influence of spinal subarachnoid space shunting in post-traumatic syringomyelia]]
 
*[[How well do 3D CFD simulations compare with 4D MRI flow measurements in the third ventricle?]]
 
*[[Finite element analysis of hydrocephalus:  influence of heterogeneous cerebrospinal fluid content and anisotropic brain permeability]]
 
 
 
'''Cardiovascular related'''
 
*[[1-D computational modeling of the impact of aortic graft implantation]]
 
*[[A prospective and controlled clinical study to evaluate the effect of ascending aortic reconstructive surgery on cardiovascular hemodynamics]]
 
 
 
= Past projects =
 
*[[Quantification of the Modulus of Elasticity and Dynamic Properties of Sylgard for Various Mixing Ratios, 2003-2006]]
 
*[[MR Measurement of Cerebrospinal Fluid Velocity Wave Speed in the Spinal Canal]]
 
*[[Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories]]
 
*[[The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis]]
 
*[[Syringomyelia Hydrodynamics: An In Vitro Study Based on In Vivo Measurements]]
 
 
 
= External links =
 
'''Cerebrospinal Fluid Research Laboratories'''
 
:[http://lhtc.epfl.ch/ EPFL Hemodynamics and Cardiovascular Technology Lab]
 
:[http://www.biofluids.net University of Akron Biofluids Lab]
 
:[http://www.smartshunt.ethz.ch/ ETH smart shunt hydrocephalus project]
 
:[http://www.eng.ox.ac.uk/fbg/ Fluidics and Biocomplexity Group]
 
:[http://www.u-picardie.fr/labo/UGBM/Index.htm Research Group Multimodal Analysis of Brain Function]
 
:[http://lppd.uic.edu/research/research.html Laboratory of Product and Process Design]
 
 
 
'''Lymphatic Research Laboratories'''
 
:[http://www.sunnybrook.ca/research/content/?page=sri_groups_lymph_home Lymphatic Research Group at Sunnybrook Toronto]
 
 
 
'''Vascular Research Laboratories'''
 
:[http://acoustics.mie.uic.edu/ University of Illinois at Chicago Acoustics and Vibrations Lab]
 
:[http://www.ices.cmu.edu/vascular-biomechanics/ CMU Vascular Biomechanics Lab]
 
:[http://www.pitt.edu/~msacks/etml.html UPitt Engineered Tissue Mechanics and Mechanobiology Lab]
 
:[http://www.surgery.upmc.edu/vorplab/bios/vorp.htm UPitt Vascular Bioengineering Lab]
 
 
 
'''Organizations and foundations'''
 
:[http://www.conquerchiari.org/index.htm Conquer Chiari.org]
 
:[http://www.asap.org American Syringomyelia Alliance Project]
 
:[http://www.columnofhope.org/ Column of Hope]
 
:[http://www.csfinfo.org/ Chiari Syringomyelia Foundation]
 
 
 
'''Societies'''
 
:[http://www.iscbfm.org/ International Society for Cerebral Blood Flow and Metabolism]
 
:[http://www.srhsb.org/ Society for Research into Hydrocephalus and Spina Bifida]
 
 
 
'''Related conferences'''
 
:[http://www.icp2010.eu/ ICP 2010]
 
:[http://www.porstmann-kongresse.de/syringomyelia2010/ Syringomyelia 2010]
 
:[http://www.hydrocephalus2008.com/copenhagen.htm International society for hydrocephalus and cerebrospinal fluid disorders]
 
:[http://www2.kenes.com/brain/pages/home.aspx International symposium on cerebral blood flow, metabolism and function]
 
:[http://www.conquerchiari.org/Res%20Conf%202010/Research%20Conference%202010.htm Conquer chiari research conference]
 
:[http://www.acns.org/ American Clinical Neurophysiology Society]
 
 
 
= References =
 
{{reflist}}
 

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links