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[[Image:projects.jpg|thumb|right|400px|Figure 1. Ongoing research projects at the Neurophysiological Imaging and Modeling Laboratory (NIML).]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
[[Image:cfd.jpg|thumb|right|400px|Figure 2. Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
[[Image:4DMRI.jpg|thumb|right|400px|Figure 3. 3D rendering of peak systolic CSF velocities in the aqueduct of Sylvius and 3rd ventricle obtained by 4D MRI imaging by [[Theresia Yiallourou]].]]
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
[[Image:banner.jpg|thumb|right|400px|Figure 4. ''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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{{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
== Welcome to the NIML ==
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [http://www.uidaho.edu/cals/bae Department of Biological Engineering] is led by Dr. [[Bryn Martin]]. Our aim is to conduct clinical translational research that enhances human health and well being for the millions of people affected by CNS disorders.  We develop and apply advanced MR imaging and computational modeling techniques to investigate the pathophysiology of CNS disorders and therapeutics from a hydrodynamic and biomechanical perspective and develop related medical technologies.  
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
== Research ==
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== Welcome to the NIML==
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies. 
  
The NIML's conducts in vivo, in vitro and in silico experiments to investigate four main areas of research (Figure 4):
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=== Team ===
#Intrathecal drug and gene vector delivery
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*[[Team]] 
#Hydrocephalus and Chiari malformation
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*[[Collaborators]]
#Medical Devices and Technology
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*[[NIML Lab Fun!]]
#Neurodegenerative disorders
 
  
=== Projects ===
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===Job Opportunities in the NIML===
Please click on the links below to learn more about the current, available, and past research projects at the NIML.
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* [[Open Positions|Open Research Assistant Positions]]
* [[Open Positions|Open Research Assistant Positions]] for projects that we need help with.   
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===Mission===
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sectorOur multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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#CSF physiology, Chiari malformation & hydrocephalus
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
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#Traumatic brain injury biomechanics
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
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=== Research ===
 
*[[Current projects]] that we are working on.
 
*[[Current projects]] that we are working on.
 
*[[Past projects]] that have been completed.
 
*[[Past projects]] that have been completed.
*Click [http://www.youtube.com/user/neurohydrodynamics here] to see Youtube videos of our research.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
=== Research Team ===
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=== Other Information ===
The NIML is a multi-disciplinary research group located at the University of Idaho and [[collaborators|collaborating institutions]]
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*[[Information for New NIML Student Researchers]]
*Click [[team|here]] to learn more about our research team.
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
*Click [[Open Positions|here]] to find open research positions in the NIML.
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*[[NIML Facilities|Facilities]] available at the NIML.
*Click [[collaborators|here]] to see our collaborators.
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*[[NIML Meeting Schedule|Monthly lab meeting]]
 
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*[[Software]] that we use in the lab.
=== Background ===
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*[[Courses]] related to Neural Engineering at University of Idaho.
*Click [[background|here]] for background on neurophysiological imaging and modeling.
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*[[Student Advising]]
 
 
=== Publications ===
 
*Click [https://scholar.google.com/citations?user=Nc4neIgAAAAJ&hl=en here] for a list of NIML publications on Google Scholar.
 
  
 
== Links ==
 
== Links ==
*Click [[links| here]] for external links to related laboratories, conferences, and organizations.
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*[[Links]] to related laboratories, conferences, and organizations.
*Past NIML monthly meetings are [[neurohydrodynamics working group meeting|here]].
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
 
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*[https://help.uidaho.edu/ UIdaho Help System]
== News ==
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
{|class="wikitable sortable" | style="background: white; border: 0px solid rgb(153, 153, 153); align="left"; padding: 1em;" style="font-size: 100%;"
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]
! align="left" width="100pt" | Date !! class="unsortable" align="left" | Announcement
 
|-
 
|  2015-08-15 ||
 
Update to be posted soon.
 
|-
 
|  2015-08-?? ||
 
Update to be posted soon.
 
|}
 
== References ==
 
{{reflist}}
 

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links