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[[Image:cfd.jpg|thumb|right|400px|Figure 1. Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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{{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
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[[Image:4DMRI.jpg|thumb|right|400px|Figure 2. 3D rendering of peak systolic CSF velocities in the aqueduct of Sylvius and 3rd ventricle obtained by 4D MRI imaging by [[Theresia Yiallourou]].]]
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
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[[Image:banner.jpg|thumb|right|400px|Figure 3. ''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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== Welcome to the NIML==
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.
  
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== Welcome to the NIML ==
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=== Team ===
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [http://www.uidaho.edu/cals/bae Department of Biological Engineering] is led by Dr. [[Bryn Martin]]. Our aim is to conduct clinical translational research that enhances human health and well being for the millions of people affected by CNS disorders.  We develop and apply advanced MR imaging and computational modeling techniques to investigate the pathophysiology of CNS disorders and therapeutics from a hydrodynamic and biomechanical perspective and develop related medical technologies.
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*[[Team]] 
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*[[Collaborators]]
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*[[NIML Lab Fun!]]
  
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=== Research team ===
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===Job Opportunities in the NIML===
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The NIML is a multi-disciplinary research group within the University of Idaho Department of Biological Engineering. 
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* [[Open Positions|Open Research Assistant Positions]]
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*Click [[team|here]] to learn more about our research team. 
 
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*Click [[Open Positions|here]] to learn more about open research positions in the NIML.
 
  
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=== Background ===
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===Mission===
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*Click [[background|here]] for background on neurophysiological imaging and modeling.
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector.  Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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#CSF physiology, Chiari malformation & hydrocephalus
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
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#Traumatic brain injury biomechanics
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling  
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#Virtual reality for medical applications
  
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== Research ==
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=== Research ===
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[[Image:projects.jpg|thumb|right|400px|Figure 4. Ongoing research projects at the Neurophysiological Imaging and Modeling Laboratory (NIML).]]
 
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The NIML's conducts in vivo, in vitro and in silico experiments to investigate four main areas of research (Figure 4):
 
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#Intrathecal drug and gene vector delivery
 
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#Hydrocephalus and Chiari malformation
 
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#Medical Devices and Technology
 
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#Neurodegenerative disorders
 
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===Projects===
 
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Please click on the links below to learn more about the current, available, and past research projects at the NIML.
 
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* [[Open Positions|Open Research Assistant Positions]] for projects that we need help with. 
 
 
*[[Current projects]] that we are working on.
 
*[[Current projects]] that we are working on.
 
*[[Past projects]] that have been completed.
 
*[[Past projects]] that have been completed.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
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=== Publications ===
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=== Other Information ===
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For a list of NIML publications at Google Scholar please click [https://scholar.google.com/citations?user=Nc4neIgAAAAJ&hl=en here].
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*[[Information for New NIML Student Researchers]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
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*[[NIML Facilities|Facilities]] available at the NIML.
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Software]] that we use in the lab.
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*[[Student Advising]]
  
 
== Links ==
 
== Links ==
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*Take a moment to visit the [http://www.youtube.com/user/neurohydrodynamics | Neurohydrodynamics Youtube channel] to see some videos of our work.
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*[[Links]] to related laboratories, conferences, and organizations.
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*Click [[links| here]] for external links to related laboratories, conferences, and organizations.
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
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*Past NIML monthly meetings are [[neurohydrodynamics working group meeting|here]].
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*[https://help.uidaho.edu/ UIdaho Help System]
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
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== News ==
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]
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{|class="wikitable sortable" | style="background: white; border: 0px solid rgb(153, 153, 153); align="left"; padding: 1em;" style="font-size: 100%;"
 
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! align="left" width="100pt" | Date !! class="unsortable" align="left" | Announcement
 
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|-
 
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|  2015-08-15 ||
 
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Update to be posted soon.
 
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|-
 
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|  2015-08-?? ||
 
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Update to be posted soon.
 
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|}
 
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== References ==
 
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{{reflist}}
 

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links

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