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[[Image:cfd.jpg|thumb|right|400px|Figure 1. Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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{{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
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[[Image:4DMRI.jpg|thumb|right|400px|Figure 2. 3D rendering of peak systolic CSF velocities in the aqueduct of Sylvius and 3rd ventricle obtained by 4D MRI imaging by [[Theresia Yiallourou]].]]
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
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[[Image:banner.jpg|thumb|right|400px|Figure 3. ''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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== Welcome to the NIML==
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.
  
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== Welcome to the NIML ==
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=== Team ===
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'''The Neurophysiological Imaging and Modeling Laboratory''' (NIML) at The University of Idaho [http://www.uidaho.edu/cals/bae Department of Biological Engineering] is led by Dr. [[Bryn Martin]]. Our aim is to conduct clinical translational research that enhances human health and well being for the millions of people affected by CNS disorders.  We develop and apply advanced MR imaging and computational modeling techniques to investigate the pathophysiology of CNS disorders from a '''hydrodynamic''' and '''biomechanical''' perspective and develop related medical technologies.
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*[[Team]] 
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*[[Collaborators]]
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*[[NIML Lab Fun!]]
  
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=== Research team ===
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===Job Opportunities in the NIML===
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The NIML seeks highly motivated and critical-thinking students who wish to participate in a dynamic multi-disciplinary research [[team]] that makes new discoveries about CNS disorders using state-of-the-art medical imaging and modeling techniques.  We are seeking motivated students for the fall 2015 semester at the University of Idaho, Department of Biological Engineering.  Click [[Open Positions|here]] to learn more about open positions.
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* [[Open Positions|Open Research Assistant Positions]]
  
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== Research ==
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===Mission===
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[[Image:projects.jpg|thumb|right|400px|Figure 4. Ongoing research projects at the Neurophysiological Imaging and Modeling Laboratory (NIML).]]
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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The NIML's research focuses on 1. Intrathecal drug and gene vector delivery, 2. Hydrocephalus and Chiari malformation, 3. Medical Devices and Technology and 4. Neurodegenerative disorders (Figure 4).  We conduct in vivo, in vitro and in silico experiments to investigate these four areas. 
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#CSF physiology, Chiari malformation & hydrocephalus
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#Intrathecal drug delivery and CSF filtration (neurapheresis)  
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#Traumatic brain injury biomechanics
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
  
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=== Publications ===
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=== Research ===
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For a list of NIML publications please click [[publications|here]].
 
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==Projects==
 
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Please click on the links below to learn more about the current, available, and past research projects at the NIML.
 
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*[[Available projects]] that we need some help with.
 
 
*[[Current projects]] that we are working on.
 
*[[Current projects]] that we are working on.
 
*[[Past projects]] that have been completed.
 
*[[Past projects]] that have been completed.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
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== NIML monthly meetings ==
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=== Other Information ===
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The NIML and collaborating institutions hosts a monthly meeting that anyone is invited to attend in person or by VOIP.  For more information on the meeting please click [[neurohydrodynamics working group meeting|here]].
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*[[Information for New NIML Student Researchers]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
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== Backgroud ==
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*[[NIML Facilities|Facilities]] available at the NIML.
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[[Image:pulsatile.jpg|thumb|right|400px|Figure 5. Pulsatile movement of cerebrospinal fluid around the spinal cord at the second cervical vertebrae level in a healthy young subject image by [[Adrien Demuralt]].]]
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Software]] that we use in the lab.
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[[Image:cervical_spinal_subarachnoid_space.jpg|thumb|right|400px|Figure 6. Three-dimensional reconstruction of the cervical spinal subarachnoid space by [[Theresia Yiallourou]] without nerve roots included.  Reconstruction based on magnetic resonance images of the cervical spinal subarachnoid space conducted on a healthy young subject.]]
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*[[Student Advising]]
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===What is neurohydrodynamics?===
 
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Click [[neurohydrodynamics|here]] for a presentation with background information on neurohydrodynamics.
 
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'''[http://en.wikipedia.org/wiki/Neurohydrodynamics Neurohydrodynamics]''' is a division of [http://en.wikipedia.org/wiki/Neuroengineering neural engineering] that investigates the  [http://en.wikipedia.org/wiki/Hydrodynamics hydrodynamics] of the neurological system in health and disease.  It applies engineering principles and design concepts to neural engineering to help close the gap between [http://en.wikipedia.org/wiki/Fluid_mechanics fluid mechanics] and [http://en.wikipedia.org/wiki/Neurosurgical neurosurgical] and [http://en.wikipedia.org/wiki/Neurological neurological] [http://en.wikipedia.org/wiki/Medicine medicine].  Neurohydrodynamics combines fluid mechanics principles with [http://en.wikipedia.org/wiki/Neuroscience neuroscience] to help improve neurological disorder healthcare in terms of medical diagnosis, monitoring, and therapy. 
 
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===Key words=== 
 
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[http://en.wikipedia.org/wiki/Neurohydrodynamics Neurohydrodynamics], [http://en.wikipedia.org/wiki/Cerebrospinal_fluid cerebrospinal fluid], craniospinal disorders,  [http://en.wikipedia.org/wiki/Chiari_malformation chiari malformation], [http://en.wikipedia.org/wiki/Syringomyelia syringomyelia], [http://en.wikipedia.org/wiki/Hydrocephalus hydrocephalus], [http://en.wikipedia.org/wiki/Neural_drug_delivery_systems neural drug delivery], [http://en.wikipedia.org/wiki/Spinal_cord#Blood_supply spinal cord blood flow], [http://en.wikipedia.org/wiki/Cerebral_blood_flow cerebral blood flow], [http://en.wikipedia.org/wiki/Cerebral_perfusion_pressure cerebral perfusion and autoregulation], [http://en.wikipedia.org/wiki/Sleep_disorders sleep disorders], [http://en.wikipedia.org/wiki/Sleep_apnea sleep apnea], [http://en.wikipedia.org/wiki/Continuous_positive_airway_pressure continuous positive airway pressure], [http://en.wikipedia.org/wiki/Computational_fluid_dynamics computational fluid dynamics], [http://en.wikipedia.org/wiki/Magnetic_resonance_angiography MRI], 4DMRI and pcMRI, [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Biomechanics#Biofluid_mechanics biofluid mechanics], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Medical_technology medical technology], [http://en.wikipedia.org/wiki/Neuromonitoring neuromonitoring].
 
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== External links ==
 
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*Take a moment to visit the [http://www.youtube.com/user/neurohydrodynamics | Neurohydrodynamics Youtube channel] to see some videos of our work.
 
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*Click [[links| here]] for external links to related laboratories, conferences, and organizations.
 
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== News ==
 
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{|class="wikitable sortable" | style="background: white; border: 0px solid rgb(153, 153, 153); align="left"; padding: 1em;" style="font-size: 100%;"
 
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! align="left" width="100pt" | Date !! class="unsortable" align="left" | Announcement
 
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|  2012-05-30 ||
 
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Dr. Martin is hired as Director of the [http://www.chiari-research.org|Conquer Chiari Research Center] at the University of Akron.
 
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|  2012-03-15 ||
 
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NIML's [http://cordis.europa.eu/fp7/dc/index.cfm?fuseaction=usersite.fp7detailscallpage&call_id=396| Marie Curie IIF] grant to host Prof. [http://www.aut.ac.nz/ibtec/aljumaily.html| Ahmed Al-Jumaily] from Aukland University of Technology at the EPFL [http://lhtc.epfl.ch| LHTC] was funded!
 
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|  2011-08-11 ||
 
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NIML submitted a [http://cordis.europa.eu/fp7/dc/index.cfm?fuseaction=usersite.fp7detailscallpage&call_id=396| Marie Curie IIF] grant to host Prof. [http://www.aut.ac.nz/ibtec/aljumaily.html| Ahmed Al-Jumaily] from Aukland University of Technology at the EPFL [http://lhtc.epfl.ch| LHTC].  Prof. Al-Jumaily will work with Dr. Martin to develop a new device for non-invasive treatment of obstructive sleep apnea with help from [[Raphael Heinzer]], M.D. and [[Jose Haba-Rubio]], M.D. at the [http://www.sommeil.ch| Center for Sleep Investigation].
 
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|  2011-07-19 ||
 
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The 1st CSF hydrodynamics symposium was a great success!  Click [http://www.multimedia.ethz.ch/conferences/2011/csf/2011-07-09/index?doi=10.3930/ETHZ/AV-9adf0f76-e71b-4f98-931d-68eefa2ddb19&autostart=false| here] for a video of Dr. Martin's talk on neurohydrodynamics, 4DMRI measurements, and in vitro modeling of CSF.
 
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|  2011-06-15 ||
 
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NIML submitted a [http://www.bertarelli-foundation.org/news/detail/article/harvard-and-epfl-launch-joint-neuroscience-programme/?tx_ttnews%5BbackPid%5D=205&cHash=6597b645d6| Bertarelli Foundation] EPFL/Harvard collaborative research grant with neurosurgeon [http://web1.tch.harvard.edu/cfapps/research/data_admin/Site171/mainpageS171P5.html| Joseph Madsen] and [http://connects.catalyst.harvard.edu/profiles/profile/person/14668| Tomer Anor].
 
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| 2010-12-01 ||
 
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Dr. Martin featured on the Chiari and Syringomyelia Foundation's exciting new researchers, [http://www.csfinfo.org/node/164| research projects and proposals].
 
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|  2010-10-02 ||
 
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NIML's research grant approved by the [http://www.snsf.ch Swiss National Science Foundation] to develop a coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system!
 
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|}
 
  
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== References ==
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== Links ==
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{{reflist}}
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*[[Links]] to related laboratories, conferences, and organizations.
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
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*[https://help.uidaho.edu/ UIdaho Help System]
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links

Retrieved from "http://niml.org/wiki/index.php?title=Main_Page&oldid=2275"