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[[Image:banner.jpg|thumb|right|400px|Figure 1. ''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
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[[Image:idaho.jpg|thumb|right|400px|The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!]]
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{{#ev:youtube|https://www.youtube.com/watch?v=KHqtsRuHTIk|400|right|MRI-based CFD simulation of CSF flow in a Chiari malformation patient by [[Soroush Pahlavian]]. |frame}}
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{{#ev:youtube|https://youtu.be/5f46ImO1lGQ|400|right|Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by [[Mohammadreza Khani]]. |frame}}
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  {{#ev:youtube|https://youtu.be/oUc2tKH9InU |400|right|A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by [[Mohammadreza Khani]]. |frame}}
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[[Image:fibers.jpg|thumb|right|400px|Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.]]
  
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[[Image:aorticgraft.jpg|thumb|right|400px|Figure 2. Artistic rendition of aortic graft implantation at the proximal and distal (thoracic) aorta. Anatomical illustration by [Chris Hutson| http://www.chrishutsonart.com] ]]
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{{#ev:youtube|https://www.youtube.com/watch?v=j6HjqMGuSjk|400|right|Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI. |frame}}
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[[Image:cfd.jpg|thumb|right|400px|Computational fluid dynamics simulation of CSF movement in the cervical spine by [[Soroush Pahlavian]] with spinal cord nerve roots and denticulate ligaments included.]]
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[[Image:3dprinteye.jpg|thumb|right|400px|3D printed eyeball and ocular nerve by [[Lucas Sass]] and [[Joshua Pluid]].]]
  
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== Welcome to the NMTL ==
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== Welcome to the NIML==
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'''The Neurohydrodynamics and Medical Technology Lab''' (NMTL) is led by [[Bryn Martin]] in conjunction with the [http://lhtc.epfl.ch Laboratory of Hemodynamics and Cardiovascular Technology] at the Swiss Federal Institute of Technology [http://www.epfl.ch (EPFL)] and [[collaborators|collaborating]] institutions.  We investigate the pathophysiology of craniospinal and cerebrovascular disorders from a '''hydrodynamic''' and '''biomechanical''' perspective and develop related medical technologies.  The purpose of neurohydrodynamics.com is to:
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The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho [https://www.uidaho.edu/engr/departments/chbe Department of Chemical and Biological Engineering] is led by Dr. [[Bryn Martin]].  We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.   
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# foster collaboration and discussion between medical doctors and engineers
 
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# provide in vivo and in vitro experimental data for improving modeling capabilities
 
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# increase interest in neurohydrodynamic disorder research
 
  
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== News ==
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=== Team ===
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{|class="wikitable sortable" | style="background: white; border: 0px solid rgb(153, 153, 153); align="left"; padding: 1em;" style="font-size: 100%;"
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*[[Team]]   
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! align="left" width="100pt" | Date !! class="unsortable" align="left" | Announcement
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*[[Collaborators]]
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|-
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*[[NIML Lab Fun!]]
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|  2011-08-11 ||
 
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NMTL submitted a [http://cordis.europa.eu/fp7/dc/index.cfm?fuseaction=usersite.fp7detailscallpage&call_id=396| Marie Curie IIF] grant to host Prof. [http://www.aut.ac.nz/ibtec/aljumaily.html| Ahmed Al-Jumaily] from Aukland University of Technology at the EPFL [http://lhtc.epfl.ch| LHTC]. Prof. Al-Jumaily will work with Dr. Martin to develop a new device for non-invasive treatment of obstructive sleep apnea with help from [[Raphael Heinzer]], M.D. and [[Jose Haba-Rubio]], M.D. at the [http://www.sommeil.ch| Center for Sleep Investigation].
 
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|-
 
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|  2011-07-19 ||
 
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The 1st CSF hydrodynamics symposium was a great success! Click [http://www.multimedia.ethz.ch/conferences/2011/csf/2011-07-09/index?doi=10.3930/ETHZ/AV-9adf0f76-e71b-4f98-931d-68eefa2ddb19&autostart=false| here] for a video of Dr. Martin's talk on neurohydrodynamics, 4DMRI measurements, and in vitro modeling of CSF.
 
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|-
 
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|  2011-06-15 ||
 
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NMTL submitted a [http://www.bertarelli-foundation.org/news/detail/article/harvard-and-epfl-launch-joint-neuroscience-programme/?tx_ttnews%5BbackPid%5D=205&cHash=6597b645d6| Bertarelli Foundation] EPFL/Harvard collaborative research grant with neurosurgeon [http://web1.tch.harvard.edu/cfapps/research/data_admin/Site171/mainpageS171P5.html| Joseph Madsen] and [http://connects.catalyst.harvard.edu/profiles/profile/person/14668| Tomer Anor].
 
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|-
 
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| 2010-12-01 ||
 
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Dr. Martin featured on the Chiari and Syringomyelia Foundation's exciting new researchers, [http://www.csfinfo.org/node/164| research projects and proposals].
 
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|-
 
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|  2010-10-02 ||
 
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NMTL's research grant approved by the [http://www.snsf.ch Swiss National Science Foundation] to develop a coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system!
 
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|}
 
  
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== Backgroud ==
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===Job Opportunities in the NIML===
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[[Image:pulsatile.jpg|thumb|right|250px|Figure 3. Pulsatile movement of cerebrospinal fluid around the spinal cord at the second cervical vertebrae level in a healthy young subject.]]
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* [[Open Positions|Open Research Assistant Positions]]
  
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[[Image:cervical_spinal_subarachnoid_space.jpg|thumb|right|250px|Figure 4. Three-dimensional reconstruction of the cervical spinal subarachnoid space without nerve roots included.  Reconstruction based on magnetic resonance images of the cervical spinal subarachnoid space conducted on a healthy young subject.]]
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===Mission===
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The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary [[team]] and [[collaborators]] includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:
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#CSF physiology, Chiari malformation & hydrocephalus
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#Intrathecal drug delivery and CSF filtration (neurapheresis)
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#Traumatic brain injury biomechanics
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#Advanced MRI and ultrasound imaging and post-processing techniques
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#Computational fluid dynamics simulation of biological flows
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#Astronaut eye and brain biomechanics
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#MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
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#In vitro modeling
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#Virtual reality for medical applications
  
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===What is neurohydrodynamics?===
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=== Research ===
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'''[http://en.wikipedia.org/wiki/Neurohydrodynamics Neurohydrodynamics]''' is a division of [http://en.wikipedia.org/wiki/Neuroengineering neural engineering] that investigates the  [http://en.wikipedia.org/wiki/Hydrodynamics hydrodynamics] of the neurological system in health and disease.  It applies engineering principles and design concepts to neural engineering to help close the gap between [http://en.wikipedia.org/wiki/Fluid_mechanics fluid mechanics] and [http://en.wikipedia.org/wiki/Neurosurgical neurosurgical] and [http://en.wikipedia.org/wiki/Neurological neurological] [http://en.wikipedia.org/wiki/Medicine medicine].  Neurohydrodynamics combines fluid mechanics principles with [http://en.wikipedia.org/wiki/Neuroscience neuroscience] to help improve neurological disorder healthcare in terms of medical diagnosis, monitoring, and therapy.  Click here for some more information on [[cerebrospinal fluid biomechanics]].
 
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===Key words=== 
 
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[http://en.wikipedia.org/wiki/Neurohydrodynamics Neurohydrodynamics], [http://en.wikipedia.org/wiki/Cerebrospinal_fluid cerebrospinal fluid], craniospinal disorders,  [http://en.wikipedia.org/wiki/Chiari_malformation chiari malformation], [http://en.wikipedia.org/wiki/Syringomyelia syringomyelia], [http://en.wikipedia.org/wiki/Hydrocephalus hydrocephalus], [http://en.wikipedia.org/wiki/Neural_drug_delivery_systems neural drug delivery], [http://en.wikipedia.org/wiki/Spinal_cord#Blood_supply spinal cord blood flow], [http://en.wikipedia.org/wiki/Cerebral_blood_flow cerebral blood flow], [http://en.wikipedia.org/wiki/Cerebral_perfusion_pressure cerebral perfusion and autoregulation], [http://en.wikipedia.org/wiki/Sleep_disorders sleep disorders], [http://en.wikipedia.org/wiki/Sleep_apnea sleep apnea], [http://en.wikipedia.org/wiki/Continuous_positive_airway_pressure continuous positive airway pressure], [http://en.wikipedia.org/wiki/Computational_fluid_dynamics computational fluid dynamics], [http://en.wikipedia.org/wiki/Magnetic_resonance_angiography MRI], 4DMRI and pcMRI, [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Biomechanics#Biofluid_mechanics biofluid mechanics], [http://en.wikipedia.org/wiki/Neuroscience neuroscience], [http://en.wikipedia.org/wiki/Neuroengineering neuroengineering], [http://en.wikipedia.org/wiki/Medical_technology medical technology], [http://en.wikipedia.org/wiki/Neuromonitoring neuromonitoring].
 
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== Research ==
 
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[[Image:projects.jpg|thumb|right|250px|Figure 5. Ongoing research projects at the Laboratory of Neurohydrodynamics and Medical Technology (NMTL).]]
 
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The '''NMTL''''s research includes in vivo, in vitro, and in silico studies that are conducted closely with medical collaborators and can be divided into projects involving 1) clinical tools and measurements and 2) modeling. Figure 5 shows ongoing projects at the NMTL with the names of key collaborators.  For a complete list of collaborators click [[collaborators|here]].
 
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===Clinical tools and measurements===
 
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:*Intraoperative aortic graft hemodynamics
 
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:*Continuous positive airway pressure (CPAP): influence on the cardiovascular and cerebrospinal fluid system
 
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:*4D MRI in craniospinal disorders
 
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:*4D MRI in cerebral blood flow and cerebrospinal fluid hydrodynamics
 
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:*Cerebrospinal fluid pulse wave velocity in craniospinal disorders
 
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===Modeling===
 
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:*Coupled cardiovascular and cerebrospinal fluid (CSF) system
 
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:*Hydrocephalus
 
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:*Spinal cord blood flow
 
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:*Aortic graft hemodynamics
 
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:*Cerebrospinal fluid: in vitro and computational fluid dynamics models
 
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===List of ongoing projects===
 
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Please click on the links below to learn more about the current, available, and past research projects at the NMTL.
 
 
*[[Current projects]] that we are working on.
 
*[[Current projects]] that we are working on.
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*[[Available projects]] for M.S. or B.S. students that we are working on.
 
 
*[[Past projects]] that have been completed.
 
*[[Past projects]] that have been completed.
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*[[Youtube videos]] of our research.
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*[https://scholar.google.com/citations?user=lcaLpj4AAAAJ&hl=en Publications] based on NIML research.
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*[[Background]] information on cerebrospinal fluid and the CNS.
  
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=== Research team ===
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=== Other Information ===
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Please click [[team|here]] to see members of the NMTL research team.  We are seeking motivated students for the fall 2011 semester and external [[collaborators]]. Please email [[Bryn Martin]] if you are interested in joining the laboratory or collaboration.
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*[[Information for New NIML Student Researchers]]
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*[[NIML Visitor Information| Visitor information]] including parking pass and directions.
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=== Publications ===
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*[[NIML Facilities|Facilities]] available at the NIML.
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For a list of NMTL publications please click [[publications|here]].
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*[[NIML Meeting Schedule|Monthly lab meeting]]
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*[[Software]] that we use in the lab.
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== External links ==
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*[[Courses]] related to Neural Engineering at University of Idaho.
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*Take a moment to visit the [http://www.youtube.com/user/csflab | NMTL Youtube channel] to see some videos of our work.
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*[[Student Advising]]
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*Click [[links| here]] for external links to related laboratories, conferences, and organizations.
 
  
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== References ==
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== Links ==
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{{reflist}}
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*[[Links]] to related laboratories, conferences, and organizations.
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*[https://uidaho.idm.oclc.org/login?url=https://uidaho.illiad.oclc.org/illiad/illiad.dll Iliad library loan system]
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*[https://help.uidaho.edu/ UIdaho Help System]
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*[https://transfer.ndc.nasa.gov/courier/web/1000@/wmLogin.html NASA NOMAD file transfer]
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*[https://www.uidaho.edu/research/entities/iric/rooms IRIC room scheduling]

Latest revision as of 18:21, 21 November 2023

The University of Idaho NIML is located in Moscow, ID within the beautiful Palouse hills of the inland northwest!
MRI-based CFD simulation of CSF flow in a Chiari malformation patient by Soroush Pahlavian.
Computer simulation of intrathecal drug dispersion in the cervical spine of a nonhuman primate by Mohammadreza Khani.
A nonuniform deforming mesh simulation of cerebrospinal fluid flow in a non-human primate by Mohammadreza Khani.
Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord measured in an in vitro flow model by 4D Flow MRI.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.

Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Chemical and Biological Engineering is led by Dr. Bryn Martin. We conduct clinical translational research to investigate the pathophysiology of central nervous system (CNS) disorders and develop related medical technologies.

Team

Job Opportunities in the NIML

Mission

The mission of the NIML is to become an internationally recognized leader in the study of the cerebrospinal fluid (CSF) system in relation to neurological disorders and to contribute to the advancement of CSF related technologies through active transfer of our know-how to the clinic and to the medical technology sector. Our multidisciplinary team and collaborators includes neurosurgeons, neurologists, neuroradiologists, engineers, artists, biologists and medical device manufacturers. Current research focus areas include:

  1. CSF physiology, Chiari malformation & hydrocephalus
  2. Intrathecal drug delivery and CSF filtration (neurapheresis)
  3. Traumatic brain injury biomechanics
  4. Advanced MRI and ultrasound imaging and post-processing techniques
  5. Computational fluid dynamics simulation of biological flows
  6. Astronaut eye and brain biomechanics
  7. MRI-based Biomarkers for amyotrophic lateral sclerosis and Parkinson's
  8. In vitro modeling
  9. Virtual reality for medical applications

Research

Other Information

Links

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