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MRI-based CFD simulation of CSF flow in a Chiari malformation patient


Visualization of arachnoid trabeculae fibers with second harmonic generation (SHG), bright field and fluorescence with DAPI stain.
Pulsatile movement of cerebrospinal fluid around the spinal cord at the second cervical vertebrae level in a healthy young subject image by Adrien Demuralt.
Computational fluid dynamics simulation of CSF movement in the cervical spine by Soroush Pahlavian with spinal cord nerve roots and denticulate ligaments included.
3D printed eyeball and ocular nerve by Lucas Sass and Joshua Pluid.


In silico, in vivo, and in vitro CSF experiments. Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), in vivo MR pulse wave velocity measurement in the spinal canal (center), and an in vitro cerebrospinal fluid system model (right).


Welcome to the NIML

The Neurophysiological Imaging and Modeling Laboratory (NIML) at The University of Idaho Department of Biological Engineering is led by Dr. Bryn Martin. Our aim is to conduct clinical translational research that enhances human health and well being for the millions of people affected by CNS disorders. We develop and apply advanced MR imaging and computational modeling techniques to investigate the pathophysiology of CNS disorders and therapeutics from a hydrodynamic and biomechanical perspective and develop related medical technologies.

Research

The NIML's conducts in vivo, in vitro and in silico experiments to investigate four main areas of research (Figure 1):

  1. Intrathecal drug and gene vector delivery
  2. Hydrocephalus and Chiari malformation
  3. Medical devices and technology
  4. Neurodegenerative disorders
  5. Ocular biomechanics in astronauts
  6. Traumatic brain injury

Projects

Please click on the links below to learn more about the current, available, and past research projects at the NIML.

Open Research Positions

The NIML is seeking to fill several Open Research Assistant Positions.

Research Team

The NIML is a multi-disciplinary research group located at the University of Idaho and collaborating institutions.

  • Click here to see our research team.
  • Click here to see our collaborators.
  • Click here to learn about the University of Idaho Neural Engineering Working Group.

Publications

  • Click here for a list of NIML publications on Google Scholar.

NIML Facilities

Click here to see the NIML's research facilities.

Background

  • Click here for background on neurophysiological imaging and modeling.

Teaching

  • Click here for information on courses at University of Idaho related to Neural Engineering.

Links

  • Click here for external links to related laboratories, conferences, and organizations.
  • Click here for external links to software that we use in our lab.
  • Click here for NIML visitor information (parking / directions).


NIML Events

  • Click here for the NIML meeting schedule.

News

Date Announcement
2016-09-16

Deadline to signup for the University of Idaho's Grand Challenges Program is September 16, 2016.

2016-07-29

Congratulations to NIML student Mohammadreza Khani on his abstract acceptance to the International Hydrocephalus and CSF Disorders Conference.

2016-05-17

Congratulations to NIML student Lucas Sass on his recent interview in the Moscow-Pullman Daily news.

2016-05-13

NIML welcomes our 2016 summer research students, Christina Gibbs, Joshua Pluid, Gabryel Conley, Tavara Freeman and Violet Gomm.

2016-04-18

Dr. Bryn Martin, Brian Cleveley and Xing Tao received funding for their collaborative Vandal Ideas Project grant.

2016-04-07

Congrats to ‪NIML researchers on their publication in the Annals of Biomedical Engineering!

2015-11-01

Congratulations to NIML researchers their publication in the Journal of Biomechanics.

References

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