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Welcome
The Neurohydrodynamics and Medical Technology Lab (NMTL) is led by Dr. Bryn Martin in conjunction with the Laboratory of Hemodynamics and Cardiovascular Technology at the Swiss Federal Institute of Technology (EPFL). We investigate the pathophysiology of craniospinal and cerebrovascular disorders from a hydrodynamic and biomechanical perspective and develop related medical technologies.
Purpose of neurohydrodynamics.com
- foster collaboration and discussion between medical doctors and engineers
- provide in vivo and in vitro experimental data for improving modeling capabilities
- increase interest in heurohydrodynamic disorder research
Key words Neurohydrodynamics, cerebrospinal fluid, craniospinal disorders, chiari malformation, syringomyelia, hydrocephalus, spinal drug delivery, spinal cord blood flow, cerebral blood flow, cerebral autoregulation, sleep disorders, sleep apnea, continuous positive airway pressure, computational fluid dynamics, 4DMRI, neuroengineering, neuroscience, biofluid mechanics, neuroscience, neuroengineering, medical technology, neuromonitoring.
Background information on neurohydrodynamics Information on cerebrospinal fluid biomechanics from an anatomical and physiological perspective is provided.
Please visit the CSF lab Youtube channel to see some videos of our work [1].
Available projects for M.S. or B.S. students
The NMTL is seeking motivated and clever students to join our research team. Please click on links below to learn more about projects that we are currently seeking people to join.
Neurohydrodynamics related
- Measurement of brain volume change due to acute modification of intracranial pressure
- Construction and MRI testing of a 3D model of the spinal subarachnoid space
- Measurement and characterization of cough induced subarachnoid space pressure wave reverberations during lumbar puncture
- What is the relative distribution of spinal subarachnoid space volumetric compliance in healthy subjects?
Sleep and breathing related
Cardiovascular related
- A prospective and controlled clinical study to evaluate the effect of ascending aortic reconstructive surgery on cardiovascular hemodynamics
- non-invasive measurement of cerebrovascular properties
- design and development of an improved vascular graft
Medical technology related
Current projects
CSF related
- Understanding the coupling of cranial blood flow and the cerebrospinal fluid system: an in vivo and in silico study
- Physiological impact of continuous positive airway pressure (CPAP) on total cerebral blood flow in healthy awake volunteers (ultrasound study)
- Are changes in intracranial pressure detectable by measurement of the cerebrospinal fluid velocity wave speed in the spinal canal?
- in vitro and in silico modeling of CSF wave transmission in the spinal subarachnoid space
- An in vitro examination of the influence of spinal subarachnoid space shunting in post-traumatic syringomyelia
- How well do 3D CFD simulations compare with 4D MRI flow measurements in the third ventricle?
- Finite element analysis of hydrocephalus: influence of heterogeneous cerebrospinal fluid content and anisotropic brain permeability
Cardiovascular related
Past projects
- Quantification of the Modulus of Elasticity and Dynamic Properties of Sylgard for Various Mixing Ratios, 2003-2006
- MR Measurement of Cerebrospinal Fluid Velocity Wave Speed in the Spinal Canal
- Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories
- The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis
- Syringomyelia Hydrodynamics: An In Vitro Study Based on In Vivo Measurements
External links
Cerebrospinal Fluid Research Laboratories
- EPFL Hemodynamics and Cardiovascular Technology Lab
- University of Akron Biofluids Lab
- ETH smart shunt hydrocephalus project
- Fluidics and Biocomplexity Group
- Research Group Multimodal Analysis of Brain Function
- Laboratory of Product and Process Design
Lymphatic Research Laboratories
Vascular Research Laboratories
- University of Illinois at Chicago Acoustics and Vibrations Lab
- CMU Vascular Biomechanics Lab
- UPitt Engineered Tissue Mechanics and Mechanobiology Lab
- UPitt Vascular Bioengineering Lab
Organizations and foundations
- Conquer Chiari.org
- American Syringomyelia Alliance Project
- Column of Hope
- Chiari Syringomyelia Foundation
Societies
- International Society for Cerebral Blood Flow and Metabolism
- Society for Research into Hydrocephalus and Spina Bifida
Related conferences
- ICP 2010
- Syringomyelia 2010
- International society for hydrocephalus and cerebrospinal fluid disorders
- International symposium on cerebral blood flow, metabolism and function
- Conquer chiari research conference
- American Clinical Neurophysiology Society
