MRI-based Subject-specific Brain Strain and Stress Mapping
From niml.org
Team
Problem
Repetitive deformation of the CNS tissue occurs over 30 million cardiac cycles per year due to intracranial pressure differences caused by the pulsatile intracranial blood flow and cerebrospinal fluid (CSF) motion. Alterations to these brain deformations may be an underlying factor that results in CNS disease(s) and/or symptomatology. The goal of this project is to use non-invasive displacement encoded stimulated echoes (DENSE) MRI measurements to map subject-specific brain strain and stress fields within the human brain in health and disease (Chiari malformation patients).