MRI-based Biomarkers for Characterization of Amyotrophic Lateral Sclerosis

The overarching goal of the proposed study is to quantify spinal cerebrospinal fluid (CSF) dynamics and geometry as a novel biomarker for ALS using magnetic resonance imaging (MRI). This technique could be utilized to allow earlier diagnosis and to identify disease subtypes. In addition quantification of CSF dynamics and geometry will be useful to identify the suitability for pharmaceutical treatment of ALS patients via intrathecal drug delivery through the CSF surrounding the brain and spinal cord.