Difference between revisions of "Hydrodynamic Simulator for Brain Therapeutic Development"

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(Team)
 
Line 5: Line 5:
 
*[[Tao Xing]]
 
*[[Tao Xing]]
 
*[[Brian Cleveley]]
 
*[[Brian Cleveley]]
 +
*[[Lucas Sass]]
  
 
==The Problem==
 
==The Problem==
 
There is a critical need to develop a hydrodynamic simulator of cerebrospinal fluid that can allow testing and optimization of brain therapeutics.  Without this simulator, many beneficial therapies may never reach the market due to exorbitant development cost.  The overarching goal of this research project is to develop and validate a laboratory bench-top system for brain therapeutic development.  Our focus will be on the mimicking the macroscale dynamics of cerebrospinal fluid motion around the brain and spinal cord.
 
There is a critical need to develop a hydrodynamic simulator of cerebrospinal fluid that can allow testing and optimization of brain therapeutics.  Without this simulator, many beneficial therapies may never reach the market due to exorbitant development cost.  The overarching goal of this research project is to develop and validate a laboratory bench-top system for brain therapeutic development.  Our focus will be on the mimicking the macroscale dynamics of cerebrospinal fluid motion around the brain and spinal cord.

Latest revision as of 22:02, 9 May 2016

Figure 1. Visualization of drug delivery to the brain and spinal cord in a non-human primate using fused CT and PET imaging (Image modified from Papisov et al. Mol Pharm, 2013.

Team

The Problem

There is a critical need to develop a hydrodynamic simulator of cerebrospinal fluid that can allow testing and optimization of brain therapeutics. Without this simulator, many beneficial therapies may never reach the market due to exorbitant development cost. The overarching goal of this research project is to develop and validate a laboratory bench-top system for brain therapeutic development. Our focus will be on the mimicking the macroscale dynamics of cerebrospinal fluid motion around the brain and spinal cord.