Difference between revisions of "Current projects"

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'''Neurohydrodynamics related'''
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[[Image:projects.jpg|thumb|right|400px|Figure 1. Ongoing research projects at the Neurophysiological Imaging and Modeling Laboratory (NIML).]]
*[[Understanding the coupling of cranial blood flow and the cerebrospinal fluid system: an in vivo and in silico study]]
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[[Image:banner.jpg|thumb|right|400px|''In silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]
*[[Physiological impact of continuous positive airway pressure (CPAP) on total cerebral blood flow in healthy awake volunteers (ultrasound study)]]
 
*[[in vitro and in silico modeling of CSF wave transmission in the spinal subarachnoid space]]
 
*[[An in vitro examination of the influence of spinal subarachnoid space shunting in post-traumatic syringomyelia]]
 
*[[How well do 3D CFD simulations compare with 4D MRI flow measurements in the third ventricle?]]
 
*[[Finite element analysis of hydrocephalus:  influence of heterogeneous cerebrospinal fluid content and anisotropic brain permeability]]
 
*[[Analytical model of normal pressure hydrocephalus]]
 
  
'''Cardiovascular related'''
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==Funding==
*[[1-D computational modeling of the impact of aortic graft implantation]]
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NIML conducts research supported by federal, foundation and corporate sponsors that include: [http://www.nih.gov NIH], [http://www.nasa.gov NASA], [http://www.idahospacegrant.org/ Idaho Space Grant], [http://ctrin.unlv.edu/ UNLV Clinical Translational Research Network], [https://inbre.uidaho.edu/ Idaho INBRE], [http://asap.org/ American Syringomyelia and Chiari Alliance Project (ASAP)], [http://voyagertherapeutics.com/ Voyager Therapeutics], [http://www.alcyonels.com/ Alcyone Lifesciences], [http://mneuro.com/ Minnetronix Neuro], [https://kbr.com/markets/government/ KBR Wyle], University of Idaho and others.
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==Research Overview==
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The NIML research program focuses on characterization and modeling of CNS structure/function/biomechanics and linking these findings to the underlying pathophysiology of neurological disorders and potential therapeutics. Researchers agree that biomechanics plays an important role in the pathogenesis and possible treatment options for CNS diseases.  Thus, engineering characterization and modeling is a critical step needed to improve clinical care for patients.
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CNS research requires multidisciplinary [[collaborators|collaboration]] to make clinical impact.  NIML's multidisciplinary research has explored the interface of engineering and life sciences that includes funding for projects with components in cognitive neuropsychology, genetics, advanced MR imaging, metabolomics, molecular biology, machine learning and intrathecal gene and drug delivery.  A summary of ongoing research projects within the NIML are listed below.
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=== Medical Devices ===
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*[[Hydrodynamic Simulator for Brain Therapeutic Development]]
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*[[NeuroTouch]] Brain tissue stiffness quantification
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*[[NeuroForce]] Physiologic CSF flow pump
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*[[NeuroFlux]] Magnetic particle drug delivery to the CNS
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*[http://www.neurochi.com NeuroChi] In vitro CSF system models
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=== Intrathecal Drug and Gene Vector Delivery ===
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*[[MR Measurement and Computational Simulation of Intrathecal Drug Dispersion in Non-human Primates]]
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=== Neurodegenerative Disease ===
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*[[MRI-based Biomarkers for Characterization of Amyotrophic Lateral Sclerosis]]
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*[[MRI-based Subject-specific Brain Strain and Stress Mapping]]
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*[[Advanced Ocular and Brain Magnetic Resonance Imaging of Astronauts Following Long Duration Space Flight]]
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*[[VIIP Scholar]]
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=== Chiari malformation and Hydrocephalus ===
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*[[Connectomic Mapping of the Human Brain With Chiari Malformation]]
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=== Art Science ===
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*[[Visualizing Science]]

Revision as of 17:43, 11 December 2018

Figure 1. Ongoing research projects at the Neurophysiological Imaging and Modeling Laboratory (NIML).
In silico, in vivo, and in vitro CSF experiments. Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), in vivo MR pulse wave velocity measurement in the spinal canal (center), and an in vitro cerebrospinal fluid system model (right).

Funding

NIML conducts research supported by federal, foundation and corporate sponsors that include: NIH, NASA, Idaho Space Grant, UNLV Clinical Translational Research Network, Idaho INBRE, American Syringomyelia and Chiari Alliance Project (ASAP), Voyager Therapeutics, Alcyone Lifesciences, Minnetronix Neuro, KBR Wyle, University of Idaho and others.

Research Overview

The NIML research program focuses on characterization and modeling of CNS structure/function/biomechanics and linking these findings to the underlying pathophysiology of neurological disorders and potential therapeutics. Researchers agree that biomechanics plays an important role in the pathogenesis and possible treatment options for CNS diseases. Thus, engineering characterization and modeling is a critical step needed to improve clinical care for patients.

CNS research requires multidisciplinary collaboration to make clinical impact. NIML's multidisciplinary research has explored the interface of engineering and life sciences that includes funding for projects with components in cognitive neuropsychology, genetics, advanced MR imaging, metabolomics, molecular biology, machine learning and intrathecal gene and drug delivery. A summary of ongoing research projects within the NIML are listed below.

Medical Devices

Intrathecal Drug and Gene Vector Delivery

Neurodegenerative Disease

Chiari malformation and Hydrocephalus

Art Science