Current projects

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Figure 1. Ongoing research projects at the Neurophysiological Imaging and Modeling Laboratory (NIML).
In silico, in vivo, and in vitro CSF experiments. Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), in vivo MR pulse wave velocity measurement in the spinal canal (center), and an in vitro cerebrospinal fluid system model (right).

Funding

NIML conducts research supported by federal, foundation and corporate sponsors that include: NIH, NASA, Idaho Space Grant, UNLV Clinical Translational Research Network, Idaho INBRE, American Syringomyelia and Chiari Alliance Project (ASAP), Voyager Therapeutics, University of Idaho and others.

Research Overview

The NIML research program focuses on characterization and modeling of CNS structure/function/biomechanics and linking these findings to the underlying pathophysiology of neurological disorders and potential therapeutics. Researchers agree that biomechanics plays an important role in the pathogenesis and possible treatment options for CNS diseases. Thus, engineering characterization and modeling is a critical step needed to improve clinical care for patients.

CNS research requires multidisciplinary collaboration to make clinical impact. NIML's multidisciplinary research has explored the interface of engineering and life sciences that includes funding for projects with components in cognitive neuropsychology, genetics, advanced MR imaging, metabolomics, molecular biology, machine learning and intrathecal gene and drug delivery. A summary of ongoing research projects within the NIML are listed below.

Medical Devices

Intrathecal Drug and Gene Vector Delivery

Neurodegenerative Disease

Chiari malformation and Hydrocephalus

Art Science