View source for CSF lab.com

[[Image:banner.jpg|thumb|right|400px|''in silico'', ''in vivo'', and ''in vitro'' CSF experiments.  Laser Doppler vibrometry surface motion analysis of an in vitro spinal cord model (left), ''in vivo'' MR pulse wave velocity measurement in the spinal canal (center), and an ''in vitro'' cerebrospinal fluid system model (right).]]

= Overview =
Welcome to the Cerebrospinal Fluid (CSF) Laboratory research website!  The CSF Lab is led by [[Bryn Martin]] in conjunction with the [[Laboratory of Hemodynamics and Cardiovascular Technology]] at the Swiss Federal Institute of Technology (EPFL) to investigate the underlying '''biomechanical''' and '''hydrodynamic''' mechanisms responsible for pathologies of the cerebrospinal and cerebrovascular systems.  Please direct questions to [[Bryn Martin]] at: mail [atz] csflab [dotz] com.

'''Purpose of CSF lab.com'''
# '''foster''' collaboration and discussion between CSF and cerebrovascular researchers
# '''provide''' in vivo and in vitro experimental data
# '''increase''' interest in CSF and craniospinal disorder research

''' Key words '''
Neurohydrodynamics, cerebrospinal fluid, craniospinal disorders,  chiari malformation, syringomyelia, hydrocephalus, spinal drug delivery, spinal cord blood flow, cerebral blood flow, cerebral autoregulation, sleep disorders, sleep apnea, continuous positive airway pressure, computational fluid dynamics, 4DMRI, neuroengineering, neuroscience,

''' Background information on neurohydrodynamics'''
Information on [[cerebrospinal fluid biomechanics]] from an anatomical and physiological perspective is provided.

= Available projects for Ph.D., M.S. or B.S. students (semester or thesis)=
'''Cerebrospinal fluid related'''
*[[Measurement of brain volume change due to acute modification of intracranial pressure]]
*[[Construction and MRI testing of a 3D model of the spinal subarachnoid space]]
*[[Measurement and characterization of cough induced subarachnoid space pressure wave reverberations during lumbar puncture]]
*[[What is the relative distribution of spinal subarachnoid space volumetric compliance in healthy subjects?]]

'''Sleep and breathing related'''
*[[Physiological impact of continuous positive airway pressure (CPAP) on cerebral blood flow and cerebrospinal fluid dynamics in healthy awake volunteers (MRI)]]

'''Cardiovascular related'''
*[[A prospective and controlled clinical study to evaluate the effect of ascending aortic reconstructive surgery on cardiovascular hemodynamics]]
*[[non-invasive measurement of cerebrovascular properties]]
*[[design and development of an improved vascular graft]]

'''Technology related'''
*[[a low-cost directional hearing aid]]

= Current projects =
Visit the CSF lab Youtube channel to see some videos of our work [http://www.youtube.com/user/csflab].

'''CSF related'''
*[[Understanding the coupling of cranial blood flow and the cerebrospinal fluid system: an in vivo and in silico study]]
*[[Physiological impact of continuous positive airway pressure (CPAP) on total cerebral blood flow in healthy awake volunteers (ultrasound study)]]
*[[Are changes in intracranial pressure detectable by measurement of the cerebrospinal fluid velocity wave speed in the spinal canal?]]
*[[in vitro and in silico modeling of CSF wave transmission in the spinal subarachnoid space]]
*[[An in vitro examination of the influence of spinal subarachnoid space shunting in post-traumatic syringomyelia]]
*[[How well do 3D CFD simulations compare with 4D MRI flow measurements in the third ventricle?]]
*[[Finite element analysis of hydrocephalus:  influence of heterogeneous cerebrospinal fluid content and anisotropic brain permeability]]

'''Cardiovascular related'''
*[[1-D computational modeling of the impact of aortic graft implantation]]
*[[A prospective and controlled clinical study to evaluate the effect of ascending aortic reconstructive surgery on cardiovascular hemodynamics]]

= Past projects =
*[[Quantification of the Modulus of Elasticity and Dynamic Properties of Sylgard for Various Mixing Ratios, 2003-2006]]
*[[MR Measurement of Cerebrospinal Fluid Velocity Wave Speed in the Spinal Canal]]
*[[Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories]]
*[[The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis]]
*[[Syringomyelia Hydrodynamics: An In Vitro Study Based on In Vivo Measurements]]

= External links =
'''Cerebrospinal Fluid Research Laboratories'''
:[http://lhtc.epfl.ch/ EPFL Hemodynamics and Cardiovascular Technology Lab]
:[http://www.biofluids.net University of Akron Biofluids Lab]
:[http://www.smartshunt.ethz.ch/ ETH smart shunt hydrocephalus project]
:[http://www.eng.ox.ac.uk/fbg/ Fluidics and Biocomplexity Group]
:[http://www.u-picardie.fr/labo/UGBM/Index.htm Research Group Multimodal Analysis of Brain Function]
:[http://lppd.uic.edu/research/research.html Laboratory of Product and Process Design]

'''Lymphatic Research Laboratories'''
:[http://www.sunnybrook.ca/research/content/?page=sri_groups_lymph_home Lymphatic Research Group at Sunnybrook Toronto]

'''Vascular Research Laboratories'''
:[http://acoustics.mie.uic.edu/ University of Illinois at Chicago Acoustics and Vibrations Lab]
:[http://www.ices.cmu.edu/vascular-biomechanics/ CMU Vascular Biomechanics Lab]
:[http://www.pitt.edu/~msacks/etml.html UPitt Engineered Tissue Mechanics and Mechanobiology Lab]
:[http://www.surgery.upmc.edu/vorplab/bios/vorp.htm UPitt Vascular Bioengineering Lab]

'''Organizations and foundations'''
:[http://www.conquerchiari.org/index.htm Conquer Chiari.org]
:[http://www.asap.org American Syringomyelia Alliance Project]
:[http://www.columnofhope.org/ Column of Hope]
:[http://www.csfinfo.org/ Chiari Syringomyelia Foundation]

'''Societies'''
:[http://www.iscbfm.org/ International Society for Cerebral Blood Flow and Metabolism]
:[http://www.srhsb.org/ Society for Research into Hydrocephalus and Spina Bifida]

'''Related conferences'''
:[http://www.icp2010.eu/ ICP 2010]
:[http://www.porstmann-kongresse.de/syringomyelia2010/ Syringomyelia 2010]
:[http://www.hydrocephalus2008.com/copenhagen.htm International society for hydrocephalus and cerebrospinal fluid disorders]
:[http://www2.kenes.com/brain/pages/home.aspx International symposium on cerebral blood flow, metabolism and function]
:[http://www.conquerchiari.org/Res%20Conf%202010/Research%20Conference%202010.htm Conquer chiari research conference]
:[http://www.acns.org/ American Clinical Neurophysiology Society]

= References =
{{reflist}}